I’ve developed a very clear strategy that works for me when I hit hardship. If I’ve just gotten bad news about something – experiments aren’t working, a departmental project fails to move forward, a grant proposal denied, or a paper gets rejected again – I now know what to do. Take a step back, clear the slate, consider all options, and make a new plan. Sometimes the best decision might be to make some minor adjustments; sometimes the decision might be to stop a project and just start fresh. But I make a plan, and then I just start taking the steps to move forward. As soon as I have a plan, I feel much better. I have direction. I may not be in the best situation at present, but at least I know how I’m going to change the situation and so I have hope.